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联合检测抗核小体抗体和抗dsDNA抗体对SLE疾病活动和脏器损害的意义

来源:中国医师杂志 作者:汪国生张… 2009-2-21

摘要: 摘要:目的 探讨联合检测抗核小体抗体(AnuA)、抗dsDNA抗体对系统性红斑狼疮(SLE)疾病活动和脏器损害的意义。方法 69例SLE分为疾病活动和疾病稳定组、狼疮肾炎(LN)和非狼疮肾炎组(NLN)。测定AnuA和抗dsDNA抗体水平,比较组间抗体水平差异,分析其与免疫指标的相关性。结果 AnuA和抗dsDNA抗体阳性率为55.1%和47.......


摘 要:

目的 探讨联合检测抗核小体抗体(AnuA)、抗dsDNA抗体对系统性红斑狼疮(SLE)疾病活动和脏器损害的意义。方法 69例SLE分为疾病活动和疾病稳定组、狼疮肾炎(LN)和非狼疮肾炎组(NLN)。测定AnuA和抗dsDNA抗体水平,比较组间抗体水平差异,分析其与免疫指标的相关性。结果 AnuA和抗dsDNA抗体阳性率为55.1%和47.82%,疾病活动组显著高于疾病稳定组(P〈0.001)。抗dsDNA抗体阴性SLE中有16,6%AnuA阳性。两抗体与SLE疾病活动指数(SLEDAI)、IgG、球蛋白水平显著正相关,与C3、C4、白蛋白水平显著负相关。LN组两抗体水平均显著高于NLN。结论 AnuA和抗dsDNA抗体都是SLE疾病活动指标,与LN相关,AnuA检测是对抗dsDNA抗体的有益补充。

关键词:

红斑狼疮,系统性 抗体,抗核 核小体 DNA

Significance of combination of serum anti-nucleosome and anti-dsDNA antibodies in patients with systemic lupus erythematosus

WANG Guo-sheng, ZHANG Hong, SHAN Shu-guang, YANG Guo-jun, QIAN Long, WANG Wei, LI Xiao-mei, LI Xiang-pei (Department of Rheumatology, Anhui Provincial Hospital, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China)

Abstract:

Objective To explore the significance of anti-nucleosome and anti-dsDNA antibodies on the disease flare and organ damage in patients with systemic lupus erythematosus (SLE). Methods Sixty-nine SLE patients were divided into disease flare group, stable group, lupus nephritis group and non-lupus nephritis group. Serum levels of anti-nucleosome antibody and anti-dsDNA antibody were measured with enzyme linked immunosorbent assay (ELISA) and indirect immunofluorescence ( IIF), respectively. Results The positive rates of serum anti-nucleosome and anti-dsDNA antibodies were 55. 10% and 47.82% respectively and the rates were significantly higher in disease flare group than those in disease stable group ( P 〈 0. 001 ). The positive rate of anti-nucleosome antibody may be positive in 16. 6% anti-dsDNA negative patients. The levels of anti-nucleosome and anti-dsDNA antibodies were positively correlated with SLEDAI, IgG and globulin and negatively with the levels of C3, C4 and albumin. Serum levels of anti-nuclesome and anti-dsDNA antibodies were higher in lupus nephritis group than those in non-lupus nephritis group. Conclusion The levels of anti-nucleosome and anti-dsDNA antibodies are index of disease activity and correlated with lupus nephritis. The detection of anti-nucleosome antibody is helpful for the diagnose of SLE patients with negative anti-dsDNA.

Lupus erythematosus,systemic; Antibodies,antinuclear; Nucleosomes; DNA



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