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曲格列酮

来源:hospital.health.163.com 作者: 2009-1-18
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摘要: 药物名称 曲格列酮 药物别名 曲格列酮、曲列他宗Noscal 英文名称 Troglitazone 说明 功用作用 With a sulfonylurea or insulin to improve control of type II diabetes。 Investigational: Use in the productive and metabolic consequences of polycystic ovary syndrome and essent......


药物名称   曲格列酮
药物别名   曲格列酮、曲列他宗Noscal
英文名称   Troglitazone
说  明   
功用作用   With a sulfonylurea or insulin to improve control of type II diabetes. Alone as an adjunct to diet and exercise to lower blood glucose. Investigational: Use in the productive and metabolic consequences of polycystic ovary syndrome and essential hypertension with type II diabetes.
用法用量   Tablets With insulin in type II diabetes mellitus. Adults, initial: 200 mg daily while continuing the insulin dosage. If the response is inadequate, the dose of troglitazone may be increased after 2 to 4 weeks. Usual daily dose: 400 mg/day. Maximum daily dose: 600 mg/day. The insulin dose should be decreased by 10% to 25% when fasting plasma glucose levels decrease to less than 120 mg/dL in clients receiving both insulin and troglitazone. With sulfonylureas in type II diabetes mellitus. Adults, initial: 200 mg once daily. Continue the sulfonylurea dose. If response is inadequate, increase the dose of troglitazone at 2 to 4 weeks, not to exceed 600 mg/day. The sulfonylurea dose may need lowering to optimize therapy. Monotherapy for type II diabetes mellitus. For those not responding to 400 mg once daily, increase the dose to 600 mg after 1 month. For those not responding adequately to 600 mg after 1 month, consider alternative therapy. Polycystic ovary syndrome. Adults: 400 mg/day.
注意事项   Pregnancy Category: B
Contraindications: Lactation. Use for type I diabetes or for the treatment of diabetic ketoacidosis.
Special Concerns: Use with caution in those with liver disease and in those with CHF. Ovulation may resume in premenopausal anovulatory clients, leading to an increased risk of pregnancy. Safety and efficacy have not been determined in children.

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