摘要：Lung-associated TFPI antigen and mRNA decreased during sepsis, and TFPI activity diminished abruptly at 2 hours。 Lung tissue samples were snap frozen in liquid nitrogen and stored at C80。Preparat...

摘要：【摘要】 Dexamethasone, a synthetic corticosteroid, is widely used as a potent anti-inflammatory drug in various diseases including corneal angiogenesis。s impact on interleukin (IL)-1ß。...

摘要：【摘要】 Bone morphogenic protein 7 (BMP7) counteracts physiological epithelial-to-mesenchymal transition, a process that is indicative of epithelial plasticity。 Because epithelial-to-mesench...

摘要：【摘要】 Notch functions as an oncogene or tumor inhibitor in various cancers, and decreases in Notch2 expression are associated with increasing grade of human breast cancer。 We constitutivel...

摘要：Thyroid carcinoma development was analyzed in CombitTA-Snail mice, in which SNAI1 levels are up-regulated。Several transcriptional repressors have been shown to modulate cadherin expression, includ...

摘要：【摘要】 The role of estrogens in the etiology of prostate cancer is controversial。 To demonstrate the specific effects of estrogens and androgens on the development of the prostatic epitheli...

摘要：【摘要】 We here examined whether c-Jun NH2 terminal kinase (JNK) might be involved in the progression of urothelial carcinomas。c-Jun NH2 terminal kinase (JNK), a member of the mitogen-activa...

摘要：Neurofibrillary inclusions developed in neurons at 3 months and were of two types, suggestive of a selective vulnerability of neurons to form different types of fibrillary aggregates。 Neurofibrill...

摘要：Tandem Mass Spectrometry Analysis and Protein IdentificationQuantitative mass spectrometry (MS) analysis was performed using the 4700 proteomics analyzer with time-of-flight (TOF)/TOF optics (Appli...

摘要：Increased Levels of the Mammalian Autophagic Protein LC3-II in Brains of Npc1C/C MiceLysosomal dysfunction perturbs normal protein degradation and amino acid recycling, which could result in a stat...

摘要：【摘要】 Activation of receptor for advanced glycation end products (RAGE) by its ligand, HMGB1, stimulates myogenesis via a Cdc42-Rac1-MKK6-p38 mitogen-activated protein kinase pathway。 In a...

摘要：Demonstration of IL-1 Pathway Activation in Tissue Cultures of Normal Articular ChondrocytesTo check whether chondrocytes are responsive in their native environment to IL-1ß。Confirmation of t...

摘要：Culture supernatant (CS) derived from PMNs also decreased allostimulation ability of immature DCs and increased the expression of transforming growth factor (TGF)-ß。 A TGF-ß。 Furthermor...

摘要：We provide evidence that both pemphigus foliaceus-IgG containing Dsg 1- but not Dsg 3-specific antibodies and pemphigus vulgaris-IgG with antibodies to Dsg 1 and Dsg 3 were equally effective in cau...

摘要：【摘要】 Immunoglobulin-secreting cells comprise both short-lived proliferating plasmablasts and long-lived nonproliferating plasma cells。-----------------------------------------------------...

摘要：【摘要】 AvrA is a newly described bacterial effector existing in Salmonella。 Here, we test the hypothesis that AvrA is a deubiquitinase that removes ubiquitin from two inhibitors of the nucl...

摘要：Myoid cells appeared particularly vulnerable to complement。17 Myoid cells are the only cells known to express whole AChR outside muscle, where lymphoid infiltrates are minimal in MG。25Myoid cells...

摘要：14Oncostatin M (OSM) is a member of the interleukin (IL)-6 cytokine family that includes IL-6, IL-11, leukemia inhibitory factor, ciliary neurotrophic factor, cardiotrophin-1, and novel neutrophin-...

摘要：Epithelial to mesenchymal transition (EMT) has been proposed as a key mechanism of myofibroblast accumulation in renal fibrosis。Identification of Infiltrating Leukocytes, CCL5, Snail1, and -SMAInf...

摘要：In Vivo Thrombosis ModelPlatelet function in vivo was assessed with a light/dye-induced model of platelet thrombus formation in cremaster venules of pentobarbital-anesthetized mice, as described pr...

摘要：Generation of the Human MR Conditional ModelSkin conditional expression of human MR (hMR) in double-transgenic (DT) mice was obtained by crossing the previously characterized tetO-hMR mice L2 line2...

摘要：Cells of the Mononuclear Phagocyte System Are a Major Source of IL-10 and Increase during the Innate Pulmonary PPD Bead Granuloma Response in Aged MiceThe above findings were consistent with the kn...

摘要：【摘要】 Aldosterone is known to regulate electrolyte homeostasis, but it may also contribute to other processes, including the maladaptive remodeling of postinfarct hearts。3Aldosterone is on...

摘要：Preparation of Cytosolic and Nuclear ExtractsCultured cells were washed with PBS, scraped off the dishes in ice-cold PBS, and centrifuged。 Nuclear proteins were obtained by centrifugation at 13,00...

摘要：【摘要】 Protease-activated receptor-2 (PAR-2) is a cellular receptor expressed prominently on epithelial, mesangial, and endothelial cells in the kidney and on macrophages。 PAR-2 is activate...

摘要：Antagonists of the renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists have been used to treat fibrotic complications of diabetes and hype...

摘要：In some cases, BALB/c mice were purchased from the National Cancer Institute (Fredrick, MD)。l) from each lavage were spun onto a slide using a cytospin centrifuge and then stained with Diff-Quick ...

摘要：Among 11 surveyed chemokine receptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CXCR) 3, and CXCR6 correlated with COPD severity as defined by criteria from the Global Initiative ...

摘要：M-CSF mobilized CXCR4+ cells into peripheral circulation, and the mobilized CXCR4+ cells were then recruited into the infarct area in which SDF-1 showed marked expression。 The CXCR4 antagonist AMD...

摘要：【摘要】 MicroRNAs (miRNAs) are a family of 21- to 25-nucleotide, noncoding small RNAs that primarily function as gene regulators。 Thanks to their discovery, cancer research has found a new a...

摘要：High glucose further increased both Txnip expression and its promoter activity in TGF-ß。 High glucose-induced ROS have been directly implicated in diabetic nephropathy。 Proteins were then tr...

摘要：Complement is an assembly of proteins found in the blood and body fluids and on cell surfaces。--------------------------------------------------------------------------------Complement was discove...