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白细胞介素12及其抗肿瘤作用

来源:中华外科杂志 作者:何松青 陈孝平 2004-10-12
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摘要: IL-12是新近发现的一种细胞因子,具有多种生物学活性,尤其是在抗肿瘤免疫和抗病毒免疫中有重要的作用。一、IL-12概况IL-12主要来源于单核/巨噬细胞、抗原递呈细胞和B细胞,是由相对分子质量为40×103和35×103两个亚单位经二硫键连接形成的异二聚体糖蛋白。p40亚单位与造血细胞生长因子受体的胞外部分同源,同源序列包括......


  四、结语

  IL-12是一种多生物学活性的细胞因子,其在抗瘤免疫中的重要作用是通过巨噬细胞、NK细胞调节的自然抵抗力以及通过Th1细胞、NK1.1+TCRint细胞、CTL细胞介导的获得性免疫之间建立联系的。IL-12调节肿瘤患者的免疫应答是肿瘤治疗的一个新的、有前途的策略。从目前研究看,未来几年的研究重点可能主要在三个方面:(1)进一步深入研究、阐明IL-12抗瘤作用机制;(2)IL-12网络性研究;(3)临床应用研究。随着对IL-12研究的深入,IL-12将成为有重要临床意义的抗肿瘤新药。

  参考文献:

  [1]Presky DH,Yang H, Minetti LJ, et al. Afunctional interleukin-12 receptor complex is composed of two β-type cytokine receptor subunits. Amn NY Acad Sci,1996,795:390-396.

  [2]Trinchier G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type I and cytotoxic lymphocytes. Blood,1995,84:4008-4011.

  [3]Sharton-Kersten T. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experiment leishmanasis. J Immunol,1995,154:5320-5326.

  [4]Marshall JD, Secrist H, Dekrugff RH, et al.IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T Lymphocytes. J Immunol,1995,155:111-117.

  [5]Rogge L,Barberis-Maino L,Biffl M,et al. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp med,1997,185:825-831.

  [6]Ling P, Gately MK, Gubler U, et al. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediates biologic activity. J Immunol,1995,154:116-119.

  [7]Joseph R, Piccotti, Kewang LI, et al. Alloantigen-reactive Th1 development in IL-12 deficient mice. J Immunol,1998, 160:1132-1138.

  [8]Lissoni P,Rovelli F,Giani L,et al. Correlation between IL-12 and IL-2 blood levels in the metastatic neoplastic disease possible inhibitory feedback system regulating their secretion. J Biol Regul Homeost Agents,1996,10:92-93.

  [9]Maddalena Vagliani, Monica Roderfo, Federica Carallo, et al. Interleukin-12 potentiates the curative effect of a vaccine based on Interleukin-2-transduced tumor cells. Cancer Res,1996,56:467-470.

  [10]Lissoni P,Fumagalli L, Rorelli F, et al. In Vivo stimulation of IL-12 secretion by subcutaneous low-dose IL-2 in metastatic Cancer patients. Br J Cancer, 1998, 77:1957-1965.

  [11]Vander Pouw Kruan TCTM, Boeije LCM, Semeenk RTT, et al. Prostaglandin-E2 is a potent inhibitor of human IL-12 production. J Exp Med,1995,181:775-783.

  [12]Christina M,kevin E, Maria, et al. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest,1998,101:1441-1452.

  [13]Yu WG,Yamamoto N, Takenaka H, et al. Molecular mechanisms underlying IFN-γ mediated growth inhibition induce during tumor inmunotherapy with IL-12. Int Immunol, 1996,8:855-865.

  [14]Anzai R,Seki S, Ogasawara K, et al. Interleukin-12 induces cytotoxic NK1+alpha beta T cells in the lungs of euthgmic and athymic mice. J Immunol, 1996,156:82-89.

  [15]Vizler C, Rosato A, Calderazzo F, et al. Therapeutic effect of interleukin-12 on mouse haemangiosarcomas is not associated with an increased anti-tumor cytotoxic T lymphocyte activity. Br J Cancer, 1998,77:656-663.

  [16]Voest EE, Kenyon BM, O′Reilly MS, et al. Inhibition of angiogenesis in vivo by interleukin-12. J Natl Cancer Inst, 1995,87:581-585.

  [17]Sgadari C, Angiolillo AL, Tostato G. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein-10.Blood,1996,87:3877-3881.


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