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神经营养因子与神经元变性研究进展

来源:解剖科学进展 作者:冯忠令任常山 2004-9-29
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摘要: 摘要:神经营养因子对于维持交感神经和感觉神经系统的生长和发育极为重要,可预防甚至逆转基底前脑胆碱能神经元变性,使学习和记忆的功能得到恢复。近年来研究其在神经元变性的机制及诊断、治疗方面有重要价值。 Brain-derived growth factor :current aspects。 Millimeter-scale positioning of a nerve-growth factor......


  摘 要:神经营养因子对于维持交感神经和感觉神经系统的生长和发育极为重要,可预防甚至逆转基底前脑胆碱能神经元变性,使学习和记忆的功能得到恢复。近年来研究其在神经元变性的机制及诊断、治疗方面有重要价值。参考文献:

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  [12]Ha DH,Robertson RT,Ribak CE,et al. Cultured basal forebrain cholinergic neurons in contact with cortical cells display synapses, enhanced morphological features, and decreased dependence on nerve growth factor. J Comp neurol, 1996, 373(3):451

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  [14]Martinez-Scrrano A,Bjorklund A. Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middleaged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging. Proc Natl Acad Sci USA,1998,95(4) :1858

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  [16]Martinez-Scrrano A,Fischer W,Soderstrom S,et al. Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain. Proc Natl Acad Sci USA, 1996,93(13):6355

  [17]Tuszynski MH,Roberts J,Senut MC, et al. Gene therapy in the adult primate brain:intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene ther, 1996,3 (4): 305

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